A natural aid for migraine prevention

Five active ingredients to significantly reduce migraine crises

It is a compound studied for the prevention of migraine with and without aura and premadrual migraine. its tablet formulation consists of:

  1. feverfew
  2. Ginger
  3. Caffeine
  4. Tryptophan
  5. Magnesium

The most important pharmacological activities are due to the PARTENIO and the ZENZERO. Parthenio has shown, with extensive studies, how it can be of particular benefit in the treatment of some types of migraine. When taken in cycles, it reduces the frequency of migraine crises and their tenderness


The most important pharmacological activities demonstrated by feverfew are:

  • Anti-inflammatory effect
  • Inhibition of platelet aggregation
  • Reduction of prostaglandin synthesis

The feverfew is rich in sesquiterpene lactones, the main one being the parthenolide which helps to prevent the excessive aggregation of platelets and inhibits the release of some chemicals that represent the inflammatory mediators.


Ginger has a recognized antioxidant and analgesic activity, with a mechanism of action similar to feverfew, as it acts in the reduction of pro-inflammatory mediators such as thromboxanes and leukotrienes.

Ginger also has antihistamine activities. Histamine is considered a molecule involved in migraine crises because it has vasodilatory activity.



It plays an important role in the production and regulation of serotonin and other neurotransmitters. Migraine sufferers have been shown to have low levels of magnesium in cerebro-spinal fluid. Migrenì increases magnesium levels in these sites


It has the function of blocking the adenosine receptors present in the nervous tissue and therefore responsible for the vasoconstriction of the blood vessels, which relieves the vascular pressure thus reducing the "headache".


L-TRYPTOPHANE (precursor of serotonin)

People suffering from migraine have lower plasma serotonin levels than others. Supplementation of L-tryptophan has been shown to reduce the severity of attacks in 86% of cases by improving painful symptoms.